Epigenetic modification in the expression of p73 p73 - epigenetic target for anticancer therapy
نویسندگان
چکیده
منابع مشابه
p73 as a Pharmaceutical Target for Cancer Therapy
About half of all human tumors contain an inactivating mutation of p53, while in the remaining tumors, the p53 pathway is frequently abrogated by alterations of other components of its signaling pathway. In humans, the p53 tumor suppressor is part of a small gene family that includes two other members, p73 and p63, structurally and functionally related to p53. Accumulating evidences indicate th...
متن کاملBRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma.
The majority of tumors arising in BRCA1 mutation carriers exhibit inactivation of p53, a key effector of cell death after DNA damage. Despite the loss of p53, BRCA1-deficient tumor cells exhibit increased sensitivity to cisplatin, and patients with BRCA1-associated ovarian carcinomas experience improved outcomes with platinum-based chemotherapy compared with sporadic cases. Although it is known...
متن کاملp73 expression and function in vestibular schwannoma.
OBJECTIVES To determine the expression of the p53 family member p73 in vestibular schwannoma (VS) and to determine the potential role of this tumor suppressor in regulating the proliferation of HEI193, a human papillomavirus E6-E7 immortalized VS cell line. METHODS Immunohistochemical staining was used to investigate the expression of p73 in 34 cases of archived VS tissue, while Western blot ...
متن کاملDecreased expression of p73 in colorectal cancer.
INTRODUCTION The colorectal cancer (CRC) is one of the most frequent cancer in Poland and worldwide. This disease is characterized by distinct genetic alterations. p73 belongs to the p53 gene family; however, its role in the pathogenesis of CRC has not been completely understood. p73 gene encodes several mRNA variants and protein isoforms with its longest and fully functional p73a (mRNA) and TA...
متن کاملAn Overview of the Epigenetic Modifications of Gene Expression in Tumorigenesis
The five leading causes of cancer-related deaths are lung (1,760,000 deaths), colorectal (862,000 deaths), stomach (783,000 deaths), liver (782,000 deaths), and breast (627,000 deaths) cancers. Epigenetic changes can alter chromatin compaction, leading to the regulation of geneexpression without changing the primary DNA sequence.Epigenetic mechanisms are normally involved incellular processes s...
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ژورنال
عنوان ژورنال: Oncology Reviews
سال: 2019
ISSN: 1970-5565,1970-5557
DOI: 10.4081/oncol.2019.421